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October 2017
Is it time for the weighted log-rank test to play a more important role in confirmatory trials?

Zheng Su, Ming Zhu
Contemporary Clinical Trials Communications
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a b s t r a c t
The log-rank test is frequently used to detect a potential treatment effect in randomized clinical trials with time-to-event endpoints. It is asymptotically the most powerful test under the proportional hazards setting, but it has been shown to markedly lose power when the proportional hazards assumption is violated.